基因中在第208位缺失一个鸟嘌呤的片段,通过同源重组替换掉了内源序列。通过Cre介导的重组,去除了一个含诺卡因选择标记的敲除载体。逆转录PCR没有检测到设计用于扩增缺失鸟嘌呤位置下游序列的引物产生的转录本。(来源:J:103713)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
基因内删除
--
1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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