CH1域(氨基酸329-379)由exon 4编码的部分被删除,下游的内含子中插入了由FRT座标记的诺卡因抗性基因座。通过表达Flp的载体短暂感染ES细胞,成功地去除了诺卡因基因座。RT-PCR在突变的MEFs中证实了这一删除。(来源:J:103607)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
基因内删除
--
1
7
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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