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中文
使用pBJR2载体，将1.5kb的neo cassette和500nt的Pgk增强子-启动子片段以反向插入，替换下游的Rasgrf1重复区域。父本重复序列的去除导致父本等位基因的甲基化丢失，通过Southern blot检测到。增强子的插入使得无论母源还是父源遗传，转录本都能表达。表达完全归功于Pgk增强子和启动子片段的插入，而非重复序列的缺失。(参考文献：J:103751, J:185711)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
