带有之前敲除Abcb1a等位基因(Abcb1atm1Bor)的ES细胞被再次用一个载体改造,该载体将Abcb1b的第3和4外显子替换为诺卡因选择标记。载体包含一个位于诺卡因 cassette 3'端的MluI酶切位点,这使得通过长距离限制性分子杂交能检测到与Abcb1a敲除关联的Abcb1b中断。(来源:J:39804)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
2
74

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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