Nt5etm2Jsc等位基因通过Cre介导的裁剪,去除了floxed exon 2和neomycin抗性基因。RT-PCR检测到的转录本长度与野生型相似,但新exon 1到3的接头处发生了框架移位,导致在第一个外显子后翻译即终止。 Western blot中未检测到蛋白质。(参考文献J:102299)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
1
17

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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