一个新霉素抗性基因座替换了包含基因exon 1到exon 2全部序列的1.86kb DNA。九个组织的Northern blot分析显示纯合突变体中未检测到可识别的mRNA表达。针对突变小鼠的支气管肺泡灌洗液,ELISA检测到了没有蛋白质。(来源:J:98708, J:102034)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
--
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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