将细菌的lacZ基因和诺卡因抗性基因片段插入到exon 1的编码区域,替换一个52bp的片段,这样内源基因的启动子驱动β-半乳糖苷酶的表达。RT-PCR结果显示肾中RNA转录水平高,而脑中则很低。这个等位基因在脑和肾中都能检测到β-半乳糖苷酶的表达。(来源:J:108655)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count