将细菌的lacZ基因插入,使其由内源性基因驱动β-半乳糖苷酶的表达。RT-PCR分析显示,大多数分析组织中检测到基因转录,但在皮肤、胆囊、骨骼肌、舌和卵巢中水平最高,骨髓和盲肠中则无转录信号可察。该等位基因的β-半乳糖苷酶表达在大脑、坐骨神经、眼睛、心脏、喉部、骨骼肌、睾丸和结缔组织中可检测到。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
--
17

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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