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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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基因编辑小鼠
Chrna2
tm1Dgen
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基础信息
表型特征
文献报道
将细菌的lacZ基因插入,使得内源性基因驱动β-半乳糖苷酶的表达。RT-PCR分析在所有测试组织中都检测到了基因转录,但这种等位基因在整体大脑基底节区域显示出强烈的β-半乳糖苷酶表达,而在大脑冠状切片上未检测到表达。在卵巢的间质中观察到适度的染色。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
3604548
129P2/OlaHsd
Targeted
插入
--
1
2
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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