将细菌的lacZ基因插入,使其由内源性基因启动子驱动β-半乳糖苷酶的表达。RT-PCR分析在所有检查的组织中都检测到了基因转录;除淋巴结和骨髓外,大多数组织中都能检测到β-半乳糖苷酶的表达。 (Source: The lacZ gene from a bacterial strain was inserted, with its endogenous promoter driving expression of beta-galactosidase. RT-PCR revealed gene transcript presence in all tissues examined, except for lymph nodes and bone marrow, where beta-galactosidase expression was detectable.)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
载体插入引起的破坏
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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