将细菌的lacZ基因插入,使其由内源性基因驱动β-半乳糖苷酶的表达。RT-PCR分析显示,除了胰腺外,大多数检测的组织中都存在基因转录;β-半乳糖苷酶在大脑、眼睛、外耳和男性生殖系统中可检测到表达。 (Source: The inserted bacterial lacZ gene is expressed under the endogenous promoter, with detectable beta-galactosidase expression in brain, eyes, external ear, and male reproductive system by RT-PCR analysis, except for the pancreas.)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
载体插入引起的破坏
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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