通过Cre介导的切除,移除了位于Igh J和Cmu基因座之间,被LoxP序列标记的诺卡因抗性基因座,它取代了Emu核心增强子。这些小鼠的B细胞数量减少,伴随着D到JH和VH到DJH重排的缺陷。(来源:J:101400)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion, Intergenic deletion
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6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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