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中文
将小鼠Prion蛋白启动子用于驱动P301L替换的人类微管关联蛋白tau的表达。杂合子小鼠表达的蛋白质水平与内源性tau相当。通过原位杂交显示了主要在神经元中的表达模式，强信号出现在大脑的 cerebellum 和 hippocampus，随后是 thalamus、hypothalamus、spinal cord、brainstem 和 cortex（来源：J:63887）。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
