Tg(PDGFB-APPSweIndArc)48Lms

These mice express human amyloid protein precursor bearing the Arctic (E22G) mutation, as well as the Swedish (K670N/M671L) and Indiana (V717F) mutations, under control of the human platelet derived growth factor, B polypeptide (PDGFB), promoter. ELISA demonstrated levels of APP and the Beta-secretase-generated C99 fragment, from which amyloid-Beta is cleaved, were higher in this line than Tg(PDGFB-APPSwIND)20Lms in hippocampus. (J:100954)