设计了一个靶向载体,旨在去除编码在exon 1内7个谷氨酰胺的(CAG)2CAA(CAG)4三重复序列。在编码序列的N端包含了一个FLAG表位标签,以便于表达。在转录起始点下游约1.3kb的位置插入了反向转录方向的floxed PGK-neo基因。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
4
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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