从第3到第7个跨膜段延伸的一个序列被替换为一个含 floxed PGK-neo 标记的元件。受体结合口袋被移除,同时氨基酸123上的ASP也一同被去掉了,这个位置对配体与受体的相互作用至关重要。删除情况通过RT-PCR和Northern blot进行了确认。(来源:J:101206)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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