设计了一个靶向载体,其在3-5号外显子周围插入了loxP位点。与小鼠中携带Cre的生殖细胞杂交后,产生了无功能等位基因,这通过检测肝脏样本的免疫印迹实验得到了验证(来源:J:101149)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
基因内删除
--
1
--
16

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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