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中文
使用大鼠enolase 2, gamma启动子驱动在神经细胞中表达人类presenilin 1（P117L突变）。该突变位于TM1和TM2域之间预测的小型细胞质环。 Western blot结果显示，转基因蛋白的表达量是内源性小鼠Psen1的两到三倍。通过原位杂交和免疫组化，证实了这种表达的广泛性和几乎特异性限于神经细胞。(引用：J:100959)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
