含有Tcrb增强子Ebeta的560bp HpaINcoI限制片段被一个由loxP序列 flank的诺卡因抗性基因座替换。随后通过Cre介导的重组移除了这个neo cassette。这些突变体通过DNA-PCR和RNA-PCR分析显示缺乏Tcrb的重排,尽管在低水平下能检测到 germ-line Vbeta转录。(来源:J:34311)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
基因间区删除
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15

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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