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中文
受精卵与两种DNA片段一同注射：一种是人CD4的cDNA与人CD2基因的启动子相连，另一种是重组自cosmid pDCbeta2片段的大DNA片段，包含人主要组织相容性复合体（MHC）II类等位基因HLA-DQA1*0301和HLA-DQB*0302，它们共同编码HLA-DQ8分子的二聚体，外加5'调控元件。在转基因小鼠的全部T细胞中，人CD4表达水平较低。在纯合的NOD小鼠中，HLA-DQ8的表达水平与野生型NOD小鼠中内源性NOD H2-Abetag7 MHC II分子相当。（来源：J:87013, J:113267）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
