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中文
这个转基因表达的是携带瑞典(K670N/M671L)和印第安(V717F)突变的人类淀粉样蛋白前体APPsweInd，由叙利亚仓鼠朊蛋白驱动的调控。转基因小鼠在大约5倍于对照小鼠的水平在大脑中表达App蛋白。在3个月大的时候，观察到了大量病理性Abeta42形式的Abeta肽的产生。(来源：J:69967)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
