将Fgfr1的内源性酪氨酸激酶区域缺失部分与兔β-球蛋白内含子下游相连,置于大鼠Gnrh1启动子/增强子区域的控制下。人类生长激素的polyA序列被插入Fgfr1 cDNA的3'端。在前脑,Gnhr1神经元所在位置,检测到约1.5kb大小的转录本,这与突变的Fgfr1大小相符。在后脑和肝脏中未发现表达。(来源:J:95057)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x DBA/2J)F2
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插入
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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