带有floxed allele Polgtm1Lrsn的鼠与表达cre普遍的鼠进行杂交,导致删除了exon 3。exon 3的缺失产生了一个框移突变,导致在exon 4早期出现终止密码子,且该基因位点几乎丧失了所有活性区域。(来源:J:99794)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count