带有floxed allele Polgtm1Lrsn的鼠与表达cre普遍的鼠进行杂交,导致删除了exon 3。exon 3的缺失产生了一个框移突变,导致在exon 4早期出现终止密码子,且该基因位点几乎丧失了所有活性区域。(来源:J:99794)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
23
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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