这个转基因包含了五个上游激活序列(UAS)元件、一个Wnt1启动子、携带W539L突变的鼠Smo cDNA、人胎盘碱性磷酸酶(ALP)的内源性核糖体进入位点驱动的cDNA、lacZ以及来自小鼠Wnt1基因的poly A信号。UAS元件驱动的是不依赖配体的突变型激活鼠Smo基因的表达,其表达依赖于GAL4的表达。(来源:J:73071)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Applicable
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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