设计了一个靶向载体,包含一个由loxP切割位点引导的转录性终止序列,紧接在人类亨廷顿病蛋白(Huntingtin)第1外显子(mhtt-exon1)的突变型polyQ-103序列后面,每个编码谷氨酰胺的重复序列,后面跟着一个polyadenylation序列。当这些携带这些序列的鼠与表达cre的特定基因驱动器动物杂交时,感兴趣的组织中会删除终止信号,从而实现mhtt-exon1的条件性表达。(来源:J:99759, J:123199)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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