将含有Hras1 cDNA和neo的盒式磁带进行拼接,使其编码部分与exon 2同源,这样一来,任何Kras产物的合成都会被阻断。在突变体中检测不到Kras蛋白。实验显示,Hras1蛋白存在于突变者大脑、心脏、肝脏、肺和脊髓中。(来源:J:98940)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
37
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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