将含有Hras1 cDNA和neo的盒式磁带进行拼接,使其编码部分与exon 2同源,这样一来,任何Kras产物的合成都会被阻断。在突变体中检测不到Kras蛋白。实验显示,Hras1蛋白存在于突变者大脑、心脏、肝脏、肺和脊髓中。(来源:J:98940)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count