将lacZ-neo cassette替换了编码HLH域和C-temrinus基因大部分序列。该 cassette 插入了内切位点,使得能够表达一个融合基因,其编码Id4 N端65个氨基酸与β-半乳糖苷酶的融合蛋白。突变大脑和睾丸的RT-PCR未检测到编码HLH域的mRNA。X-gal染色显示融合基因的表达与内源基因(J:98270)的表达相似。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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