设计了一个靶向载体,用于替换编码第9位丝氨酸(S9)的exon 1,通过将丝氨酸替换为阿尔法亚麻酸(S9A)。同时在exon 1的3'末端插入了带有floxed Neo抗性筛选元件。随后通过与表达Cre重组酶的Bal1小鼠(Tg(Nes-cre)1Wme)杂交,移除了这个floxed Neo筛选元件。(来源:J:98263)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
核苷酸替换
--
1
--
43

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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