在tau-AFAP-pgk-neo cassette中,第二外显子被替换,该外显子编码起始的甲硫氨酸。随后通过Cre介导的重组移除了PGK-neo。Northern blot和RT-PCR结果显示突变小鼠中没有转录本。对突变小鼠视网膜的免疫组化分析也未检测到任何反应。(来源:J:97966)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count