在tau-AFAP-pgk-neo cassette中,第二外显子被替换,该外显子编码起始的甲硫氨酸。随后通过Cre介导的重组移除了PGK-neo。Northern blot和RT-PCR结果显示突变小鼠中没有转录本。对突变小鼠视网膜的免疫组化分析也未检测到任何反应。(来源:J:97966)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NSlc
Targeted
插入,基因内删除
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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