LoxP位点被引入到修饰了第4外显子,该外显子包含所有Y家族聚合酶所共有的DE聚合酶motifs。通过Cre表达,这种在ES细胞中实现4号外显子的剔除,导致3-5号外显子的直接拼接。非同框的接合点会引入终止密码,产生一个由102个氨基酸组成的截短蛋白。(来源:J:98037)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
基因内删除
--
1
1
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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