目标等位基因携带有frt标记的neo cassette和一个被floxed的exon 5。随后通过瞬时表达Flp重组酶,移除了neo cassette,导致exon 5被loxP-frt(上游)和loxP(下游)序列所 flank。在纯合小鼠大脑的 Western blot 检测中,显示了正常isoform谱和表达水平。(来源:J:96990)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
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1
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9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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