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中文
在基因的启动子上游插入了loxP-Stop-loxP的转录停止元件，并对exon 2的p.L25Q和p.W26S突变进行了替换(替换为TTATGG为CAATCG)，这种策略被称为敲入。对用腺病毒Cre处理的突变MEFs进行Northern和Western印迹分析显示，转录和蛋白质分别得到了表达，但没有Cre表达的情况下不表达。(来源：J:96433)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
