在内皮2染色体上放置了一个floxed neo抗药性基因座,同时在exon 1的5'端插入了一个loxP位点。短暂的Cre表达导致了exon 1(包含起始密码子)和exon 2(包含大部分催化区域)的剔除,以及neo抗药性基因座的去除。(来源:J:96775)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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