Tg(LPV-TAg121*E107K)4Tvd

This transgene consists of a lymphotrophic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues. The transgene also harbors a C4500T point mutation causing a glutamic acid to lysine substitution at aa 107, disrupting the Rb1 binding domain. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. (J:72121)