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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Kdr
tm1.1Msh
Alias:
Flk-1
1173F
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基础信息
表型特征
文献报道
设计了一个靶向载体,目标是将Y1173F的替换(由TAT变为TTC)引入第27号外显子。与在生殖细胞中表达Cre的 mice杂交导致26号内含子的floxed neo被删除。E8.5-E9.5期的表达水平通过RT-PCR检测显示正常。(来源:J:96124)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
3530468
129P2/OlaHsd
Targeted
Insertion, Nucleotide substitutions
--
1
2
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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