通过将DraIII和SmaI限制酶酶切位点融合,删除了编码alphaLm球形( LG)5区域的7个外显子,形成了一个内切框缺失。在终止密码子后插入了neo-HSV-tk,周围有loxP标记。末端的341个氨基酸被删除,alpha1LG3和alpha1LG4之间的链接区域,以及alpha1LG4域的第一个β螺旋的短序列被保留。(来源:J:96100)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
载体插入引起的破坏
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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