在exon 2的上游插入了loxP位点,然后在exon 4的下游插入了一个可删除的neo-tk cassette。通过在正确靶向的ES细胞中短暂表达Cre重组酶,去除了neo-tk cassette。这些突变动物携带了loxP标记的exons 2-4。(来源:J:96039)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入
--
1
1
13

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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