人类SERPINA1基因从nt-1200到+46bp的片段被克隆到了HBV X基因,后者来自adwsub2/sub亚型,这个构建被插入到了包含T7噬菌体启动子的PGEM1载体中。构建中整合了10-15个转录本。转录基因在肝脏中表达得到了检测。(来源:J:90305)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count