A 1.8 kb fragment containing a mutant human TP53 with an arginine to histidine mutation at codon 273 was cloned into the EcoRI site of the rabbit Beta-globin exon 3 and placed under the transcriptional control of the human Surfactant associated protein C (SFTPC) promoter. ~7 copies of the transgene were incorporated into the genome. (J:80317)