在编码第12个抑制性域和截短的第13个抑制性域连接区的序列中引入了一个过早的终止密码子(R820X),导致了exon 26的中断。随后在exon 26内部,插入了一个由loxP序列标记的neo基因。突变小鼠的转录水平通过实时PCR分析显示低于野生型对照,(来源:J:95549)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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