一个新霉素抗性基因替换了2-4号外显子。RT-PCR结果显示,突变动物的转录本缺少这些外显子,而1号外显子连接到5号时形成了一个拼接的mRNA,其中由于框移导致了一个终止密码子,如果翻译完整,会产生一个14氨基酸的肽段。(来源:J:95518)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
9
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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