在exon 1插入了lacZtAceCreNeo的插入片段,并在exon 3放置了终止密码子。在突变等位基因通过有性生殖传递时,tAceCreNeo cassette会自动剪切。Northern blot结果显示该基因不进行转录。在杂合子中,LacZ的表达非常低或不存在,但在纯合子中则有表达。(来源:J:117073)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count