一段包含exons 1和2中ORF的序列被替换成lacZ-PGK-neo cassette。突变体大脑的Northern blot结果显示Nkx6-2转录缺失,但检测到两个与lacZ探针匹配的信号。X-gal染色显示lacZ在突变胚胎的神经元和后天的 oligodendrocytes中前期和后期都表达。(来源:J:94807)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count