一段包含exons 1和2中ORF的序列被替换成lacZ-PGK-neo cassette。突变体大脑的Northern blot结果显示Nkx6-2转录缺失,但检测到两个与lacZ探针匹配的信号。X-gal染色显示lacZ在突变胚胎的神经元和后天的 oligodendrocytes中前期和后期都表达。(来源:J:94807)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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