一种来自Ffgr1 splice variant IIIc的主导负性小鼠Fgfr受体,通过兔β球蛋白内含子的增强序列和人类生长激素基因的polyA序列包裹,然后被克隆并插入Tyrosinase相关蛋白-1(Tyrp1)启动子下游。在E10.5时,这种转录本在视网膜色素上皮中显示出高水平的转录,但在细胞完全分化和着色前,未在黑色素细胞系中检测到。眼睛表现出形态异常和整体尺寸显著减少。(来源:J:64993)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x CBA)F2
--
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部