Tg(Tyrp1-Fgfr1*IIIc)3Sjav

A dominant-negative murine Fgf receptor derived from the Ffgr1 splice variant IIIc was flanked by enhancer sequences from a rabbit Beta globin intron and polyA sequence from the human growth hormone gene. This construct was then cloned downstream of the Tyrosinase related protein-1 (Tyrp1) promoter. A high degree of transgene expression was detected in the retinal pigment epithelium by E10.5, but was not detected in the melanocytic lineage prior to cells becoming fully differentiated and pigmented. Eyes showed morphological abnormalities and a gross reduction in size. (J:64993)