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中文
Exon 14编码的活性位点对应于这种负责激活ISG15共价修饰的酶。在Exon 14上游插入了LoxP位点，下游则有Exon 18处。此外，Exon 18下游还插入了Frt-和LoxP介导的诺卡因抗性元件。通过Southern blotting确认了靶向性。同为IFN-β处理过的同源纯合子脾细胞和胸腺细胞，因其诺卡因插入，mRNA转录本相对对照有所增大。同源纯合子小鼠的组织提取物未显示出ISG15与大分子蛋白复合物的共价修饰（即无ISGylation活性）。（来源：J:144149）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
