Log In|Sign Up
中文
在exon 11的第971位，通过同源重组引入了丝氨酸到Alanine的替换(S971A)。在exon 11上游，通过同源重组插入了一个可删除的neo cassette。与在生殖细胞中表达Cre重组酶的 mice杂交后，这个带有floxed neo的基因被剪切。这个突变导致Chek2的磷酸化位点发生改变。RT-PCR结果显示，转录本的表达水平与野生型相当。(来源：J:94114)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
