Gabbr1^tm2.1Bet

Crossing Gabbr1tm2Bet with Cre-deleter mice resulted in this allele in which exons 7 and 8 are replaced with a single lox511 site. This region is involved in GABA-binding and the removal of the exons caused a frame shift that prevented translation of the full-length protein. Immunoblot indicated the lack of protein in brain extracts from mutants. (J:94234)