在loxP位点附近,替换了包含DNA酶I敏感性位点IV(HS IV)的1.9kb区域,HS IV位于Il4和Kif3a基因之间,是一个Il4的抑制子。短暂的Cre重组酶表达在ES细胞中移除了neo cassette。突变细胞的DNA酶敏感性分析显示HS IV缺失,但其他敏感位点未受影响。(来源:J:94039)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S6/SvEvTac
Targeted
载体插入引起的破坏
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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