Exon 3被两个loxP位点前后包夹,接着是一个可删除的neo cassette。在胚胎干细胞中,通过转染驱动Cre重组酶表达的载体,neo cassette被去除了,使得Exon 3仍被loxP位点锁定。淋巴结B细胞的 Western blot分析显示,表达水平与野生型无异。(来源:J:93890)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入
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1
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20

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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