从2到9号外显子,编码1到121个氨基酸的部分被一个由loxP序列标记的诺卡因抗性基因替换。这些突变体与携带Cre基因敲除的剔除小鼠(Tg(CMV-cre)1Cgn)杂交后,删除了诺卡因 cassette。对BMMCs的免疫印迹结果显示,这种等位基因不产生蛋白质表达。(来源:J:93950)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
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9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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